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# Signal-induced recruitment and dispatchment in reconfigurable phase-separated protocell networks

## Details

**Authors** Yin et al.

**Year** 2026

**Publisher** Nature Chemistry

**Discipline** Chemistry

**Secondary disciplines** Biology

[Read it at the publisher](https://doi.org/10.1038/s41557-026-02225-3) 
10.1038/s41557-026-02225-3

## In authors' words

### Abstract

The construction of protocell networks with self-regulated spatial dynamics and functions is an important challenge in the emerging field of colloidal systems chemistry. Existing strategies predominantly produce protocell networks with fixed or randomly distributed spatial organization, relying on direct surface interactions or externally imposed conditions, while largely overlooking dynamic interactions with the surrounding environment, thereby limiting the emergence of reconfigurable network behaviours. Here we demonstrate chemical strategies for implementing the spontaneous segregation and selective translocation of binary/ternary populations of enzyme-containing proteinosomes in dextran droplet/polyethylene glycol aqueous phase-separated media. The segregated proteinosomes exhibit tunable membrane wettability, engage in cross-community chemical signalling and undergo signal-induced reversals in phase compatibility to produce reconfigurable networks capable of protocell-mediated recruitment and dispatchment. We exploit the protocell phase dynamics to spatiotemporally modulate DNase I activity in a subpopulation of translocating proteinosomes. Our methodology provides a platform for developing protocell communities with self-regulated spatiotemporal order and offers opportunities in cytomimetic modelling and colloidal systems chemistry.

### What they found (results)

Enzyme-generated chemical signals reversibly alter the phase compatibility of membrane-bound protocells, allowing researchers to selectively recruit protocells into, or dispatch them from, a shared droplet phase, generating self-organizing, reconfigurable protocell networks.

## Commentary

### In short

A chemical signal acting on protocells (R) flips a phase-compatibility boundary that gates membership in a shared droplet phase (D), and the resulting recruit/dispatch dynamics assemble individual protocells into an emergent, reconfigurable networked whole (S) — the finding needs all three to hold.

**Patterns it shows** D, S, R

**Added** 2026-08-21

**How to cite this** Yin et al. (2026). Signal-induced recruitment and dispatchment in reconfigurable phase-separated protocell networks. Nature Chemistry.