[DSRP Evidence](https://dsrpevidence.org/)

# Topological mixing and irreversibility in animal chromosome evolution

Schultz et al., 2026, Science Advances — Evolutionary Biology

Patterns: [Distinctions](https://dsrpevidence.org/pattern/distinctions), [Systems](https://dsrpevidence.org/pattern/systems)

## In short

Chromosomal fusion events combine parts into new irreversible wholes, showing composition (S) is gated by a one-way category boundary (D).

## What they found (results)

Comparing more than 5,800 chromosome-scale genomes across 4,454 species and 19 phyla, fusion events that intermix gene content proved irreversible, leaving permanent one-way markers, with lineages clustering into distinct regions of a genome-architecture space.

These researchers were not testing DSRP. The finding is theirs; the correspondence to DSRP is drawn by this site.

[Source](https://doi.org/10.1126/sciadv.adz5561)